The electrocardiogram (ECG) is an essential clinical tool for the non-invasive assessment of cardiac function. Computational simulations of ECGs using bidomain models are considered the biophysically most detailed approach, but computational costs are significant. Alternatively, pseudo-bidomain formulations can be used, combining a monodomain model with an infrequent bidomain solve to obtain full extracellular potential (e) distributions and traces. However, previous attempts at such approaches did not see the expected significant decrease in compute time and did not include important effects of bathloading on activation wavefront morphology (present in full bidomain models), representing a less accurate source term for e solution. ECG traces can also be derived from computationally cheaper e recovery techniques, whereby the time-course of e is approximated at a particular point using the monodomain transmembrane potential as source term. However, e recovery methods also assume tissue to be immersed in an unbounded conductive medium; not the case in most practical scenarios. We recently demonstrated how bath-loading effects in bidomain simulations could be replicated using an augmented monodomain model, faithfully reproducing bidomain wavefront shapes and activation patterns. Here, a computationally-efficient pseudobidomain formulation is suggested which combines the advantages of an augmented monodomain method with an infrequent bidomain solve, providing activation sequences, ECG traces and e distributions in a bounded medium surrounding the heart which closely match those of the full bidomain, but at 10% the computational cost. We demonstrate the important impact of both bath-loading and a finite surrounding bath on spatiotemporal e distributions, thus demonstrating the utility of our novel pseudo-bidomain model in ECG computation with respect to previous pseudo-bidomain and e recovery approaches.
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